DNA-decorated carbon nanotube-based FETs as ultrasensitive chemical sensors: Discrimination of homologues, structural isomers, and optical isomers

We have explored the abilities of all-electronic DNA-carbon nanotube (DNA-NT) vapor sensors to discriminate very similar classes ofmolecules.We screened hundreds of DNA-NT devices against a panel of compounds chosen because of their similarities. We demonstrated that DNA-NT vapor sensors readily discriminate between series of chemical homologues that differ by single methyl groups. DNA-NT devices also discriminate among structural isomers and optical isomers, a trait common in biological olfactory systems, but only recently demonstrated for electronic FET based chemical sensors. Disciplines Physical Sciences and Mathematics | Physics Comments Khamis, S. M., Jones, R. A., Johnson, A. T. C., Preti, G., Kwak, J., & Gelperin, A. (2012). DNA-decorated carbon nanotube-based FETs as ultrasensitive chemical sensors: Discrimination of homologues, structural isomers, and optical isomers. AIP Advances, 2(2), 022110. doi: 10.1063/1.4705394 © 2012 Author(s). This article is distributed under a Creative Commons Attribution 3.0 Unported License. Author(s) S. M. Khamis, R. A. Jones, A.T. Charlie Johnson Jr., G. Preti, J. Kwak, and A. Gelperin This journal article is available at ScholarlyCommons: http://repository.upenn.edu/physics_papers/244 AIP ADVANCES 2, 022110 (2012) DNA-decorated carbon nanotube-based FETs as ultrasensitive chemical sensors: Discrimination of homologues, structural isomers, and optical isomers S. M. Khamis,1,a R. A. Jones,1 A. T. C. Johnson,1,b G. Preti,2,3 J. Kwak,2 and A. Gelperin2,4,b 1Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA 2Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA 3Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA 4Princeton Neuroscience Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA (Received 5 March 2012; accepted 26 March 2012; published online 17 April 2012) We have explored the abilities of all-electronic DNA-carbon nanotube (DNA-NT) vapor sensors to discriminate very similar classes of molecules. We screened hundreds of DNA-NT devices against a panel of compounds chosen because of their similarities. We demonstrated that DNA-NT vapor sensors readily discriminate between series of chemical homologues that differ by single methyl groups. DNA-NT devices also discriminate among structural isomers and optical isomers, a trait common in biological olfactory systems, but only recently demonstrated for electronic FET based chemical sensors. Copyright 2012 Author(s). This article is distributed under a Creative Commons Attribution 3.0 Unported License. [http://dx.doi.org/10.1063/1.4705394]